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฀TransitโปรดเองBOARD OF DIRECTORS AND EXECUTIVE SECRETARYIn vitro effect of valaciclovir on replication of HSV-2 and HSV-1 and its penetration into cells. The aim of this study was to evaluate the activity of valaciclovir (VACV) against herpes simplex virus (HSV-1 and HSV-2) in vitro, the influence of this drug on the penetration of the virus into the host cells and its influence on the virus maturation. The anti-HSV-2 activity of VACV was tested against a laboratory strain (HSV-2F), as well as clinical strains of HSV-1 (strains KOS and SK), HSV-2 (strains KOS, McKrae, F), and HSV-1/HSV-2 co-infection (strain 17). The drug was also assayed against HSV-1 and HSV-2 in the presence of the inhibitor idoxuridine (IDU). The IDU-sensitive system and the IDU-resistant one were also used in the study of the penetration of the drug into the host cells. VACV exhibited a dose-dependent inhibition of replication of HSV-2 with an ID(50) of 0.10 micromol/l. Its anti-HSV-2 activity was not affected by the presence of IDU. The drug inhibited both HSV-1 and HSV-2 but the ID(50) was higher for HSV-2 (ID(50) = 1.01 micromol/l). VACV showed good penetration into HeLa cells (28%) and Vero cells (22%). The drug exhibited a significant penetration into HSV-1 and HSV-2-infected cells. The ID(50) of VACV was 8 micromol/l, as evaluated by the ID(50) of IDU in the IDU-sensitive system. The obtained data indicate that VACV is an effective drug against HSV-1 and HSV-2, and may be useful in the therapy of recurrent oro-genital herpes.Role of transrectal ultrasound in the localisation of prostate carcinoma. Transrectal ultrasound (TRUS) is well known for its utility in the evaluation of the prostate gland, especially in the pre




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Endodonzia Castellucci Pdf machein

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